There was never any mystery in the limitations of evolutionary theory. In general, severe, almost certainly fatal, mathematical challenges have always stood in the way of selectionist assumptions. In a now classic text, Evolution From Space, Hoyle and Wickramasinghe give one version of this objection.

Darwinian evolution is most unlikely to get even one polypeptide right, let alone the thousands on which living cells depend for their survival. This situation is well known to geneticists and yet nobody seems prepared to blow the whistle on the theory.

This viewpoint has been ‘refuted’ so many times that we forget genetic research has essentially confirmed it with the discovery of new developmental structures and processes. The full random run is in fact ‘compressed’ by the existence of some other process of development. In general, be wary of statistical reasoning applied to evolution. Even the suspicion of a directional process will throw any calculations here out of kilter. The amount of sophistry attempting to counter Hoyle, strewn over the Internet, is remarkable.